An Empirical Study of China-Australia Bilateral Trade Potential Based on Gravity Model

Based on the use of trade integration index and gravity model, this paper uses the bilateral goods trade data between China and Australia from 2000 to 2019 to analyze the trade status, trade complementarity and trade potential between China and Australia. The results of the study show that the trade scale, trade complementarity and trade potential between China and Australia are constantly expanding. However, from the perspective of trade balance, China has always been in the position of a deficit country, and the deficit is getting larger and larger, especially in terms of primary products. Judging from the trade integration index, China’s trade integration with Australia generally shows an upward trend, indicating that the trade dependence between China and Australia is gradually increasing. Judging from the results of the trade potential analysis, the trade potential between the two countries has not been fully realized, and there is still much room for improvement in bilateral trade relations

Detection of False Data Injection Attacks Using the Autoencoder Approach

State estimation is of considerable significance for the power system operation and control. However, well-designed false data injection attacks can utilize blind spots in conventional residual-based bad data detection methods to manipulate measurements in a coordinated manner and thus affect the secure operation and economic dispatch of grids. In this paper, we propose a detection approach based on an autoencoder neural network. By training the network on the dependencies intrinsic in 'normal' operation data, it effectively overcomes the challenge of unbalanced training data that is inherent in power system attack detection. To evaluate the detection performance of the proposed mechanism, we conduct a series of experiments on the IEEE 118-bus power system. The experiments demonstrate that the proposed autoencoder detector displays robust detection performance under a variety of attack scenarios.Comment: 6 pages, 5 figures, 1 table, conferenc

Fault location of distribution network with distributed generation based on Karrenbauer transform and support vector machine regression

As the capacity and scale of distribution networks continue to expand, and distributed generation technology is increasingly mature, the traditional fault location is no longer applicable to an active distribution network and "two-way" power flow structure. In this paper, a fault location method based on Karrenbauer transform and support vector machine regression (SVR) is proposed. Firstly, according to the influence of Karrenbauer transformation on phase angle difference before and after section fault in a low-voltage active distribution network, the fault regions and types are inferred preliminarily. Then, in the feature extraction stage, combined with the characteristics of distribution network fault mechanism, the fault feature sample set is established by using the phase angle difference of the Karrenbauer current. Finally, the fault category prediction model based on SVR was established to solve the problem of a single-phase mode transformation modulus and the indistinct identification of two-phase short circuits, then more accurate fault segments and categories were obtained. The proposed fault location method is simulated and verified by building a distribution network system model. The results show that compared with other methods in the field of fault detection, the fault location accuracy of the proposed method can reach 98.56%, which can enhance the robustness of rapid fault location

Effect of suction chamber baffles on pressure fluctuations in a low specific speed centrifugal pump

In order to study the effect of suction chamber baffles on hydraulic performance and unsteady characteristics in a low specific speed centrifugal pump, a model pump was design with enlarging flow mothed and four schemes of suction baffle, including no baffle (scheme 0), only one baffle in the suction (scheme 1), two baffles (scheme 2) and three baffles in the suction (scheme 3), were considered. Commercial code FLUENT was applied to simulate the flow of the pump. RNG k-ε turbulence model was adopted to handle with the turbulent flows in the pump. The sliding mesh technique was applied to take into account the impeller-volute interaction. Based on the simulation results, the hydraulic performance and pressure fluctuations were obtained and analyzed in detail. The head value of no baffle in the suction (scheme 0) is lower than that with baffles in the suction (scheme 1, scheme 2, scheme 3) at each condition point. Hump point in scheme 0 is at φ= 0.00596 (1.2 times Qo). The hump point in scheme 1, scheme 2, scheme 3 is at 0.8Qo, 1.0Qo, 1.0Qo, respectively. The ε value of scheme 1 is the smallest and that of scheme 0 is the largest in the four schemes. Six wave troughs are observed clearly at each monitoring point as the impeller rotates in a circle. Each time the impeller is turned 10 degrees, there are six obvious troughs around the impeller. With the rotation of the impeller, peak value of pressure fluctuations at blade passing frequency (BPF) is gradually decrease. At low flow (ϕ= 0.002383), the main frequency of pressure fluctuation at P36 and P1 under scheme 0, scheme 2 and scheme 3 is 295 Hz, which is corresponding to BPF. The pressure fluctuation levels are decreased by –2.72 %, –2.13 %, and –2.21 % respectively when the number of baffle in the suction is one, two, three, respectively. And decrease rate of pressure fluctuation (∆Cp) on scheme 1 is maximum. It indicates that Adding baffles to the suction chamber is beneficial to reduce the amplitude of pressure pulsation at BPF in the volute. The best number of baffles in the suction is one. Based on scheme 1 simulation results, the prototype was manufactured and the performance experiments were carried out. A good agreement of the head and efficiency between numerical results and experimental results are observed

Biomimetic recombinant of red blood cell membranes for improved photothermal therapy

Background: RBC membrane derived nanoparticles (NPs) represent an emerging platform with prolonged circulation capacity for the delivery of active substances. For functionalize derived RBCs NPs, various strategies, such as biomimetic rebuilding of RBCs, chemical modification or inserting ligands, have been carried out to improve their performance. However, one potential adverse effect for these methods is the structural failure of membrane proteins, consequently affecting its original immune escape function. Results: In this study, we reported a green technology of “disassembly-reassembly” to prepare biomimetic reconstituted RBCs membrane (rRBCs) by separating the endogenous proteins and lipids from nature RBC membrane. IR780 iodide was used as a pattern drug to verify the property and feasibility of rRBCs by constructing IR780@rRBC NPs with IR780@RBC NPs and free IR780 as controls. The results demonstrated the superiority of IR780@rRBC NPs in toxicity, stability, pharmacokinetics and pharmacodynamics compared with IR780@rRBC and free IR780. Conclusions: The reported “disassembly-reassembly” strategy shows great potential to produce controllable and versatile rRBC membrane-inspired delivery platform, which may be used to overcome the deficiency of functionalization in cell membrane coated nanoparticles

RNA splicing factor USP39 promotes glioma progression by inducing TAZ mRNA maturation

Increasing evidence demonstrates that ubiquitin specific protease 39 (USP39) plays an oncogenic role in various human tumors. Here, using expression analysis of the publicly available Oncomine database, clinical glioma patient samples, and glioma cells, we found that USP39 was overexpressed in human gliomas. Knockdown of USP39 in glioma cells demonstrated that the protein promoted cell growth, invasion and migration in vitro and in a tumor model in nude mice. To identify mediators of USP39 growth-promoting properties, we used luciferase reporter constructs under transcriptional control of various promoters specific to seven canonical cancer-associated pathways. Luciferase activity from a synthetic TEAD-dependent YAP/TAZ-responsive reporter, as a direct readout of the Hippo signaling pathway, was decreased by 92% in cells with USP39 knockdown, whereas the luciferase activities from the other six cancer pathways, including MAPK/ERK, MAPK/JNK, NFκB, Notch, TGFβ, and Wnt, remained unchanged. TAZ protein expression however was decreased independent of canonical Hippo signaling. Immunohistochemistry revealed a positive correlation between USP39 and TAZ proteins in orthotopic xenografts derived from modified glioma cells expressing USP39 shRNAs and primary human glioma samples (p < 0.05). Finally, loss of USP39 decreased TAZ pre-mRNA splicing efficiency in glioma cells in vitro, which led to reduced levels of TAZ protein. In summary, USP39 has oncogenic properties that increase TAZ protein levels by inducing maturation of its mRNA. USP39 therefore provides a novel therapeutic target for the treatment of human glioma.publishedVersio

Co-delivery of salinomycin and curcumin for cancer stem cell treatment by inhibition of cell proliferation, cell cycle arrest, and epithelial-mesenchymal transition

Malignant cancer is a devastating disease often associated with a poor clinical prognosis. For decades, modern drug discoveries have attempted to identify potential modulators that can impede tumor growth. Cancer stem cells however are more resistant to therapeutic intervention, which often leads to treatment failure and subsequent disease recurrence. Here in this study, we have developed a specific multi-target drug delivery nanoparticle system against breast cancer stem cells (BCSCs). Therapeutic agents curcumin and salinomycin have complementary functions of limiting therapeutic resistance and eliciting cellular death, respectively. By conjugation of CD44 cell-surface glycoprotein with poly(lactic-co-glycolic acid) (PLGA) nanoparticles that are loaded with curcumin and salinomycin, we investigated the cellular uptake of BCSCs, drug release, and therapeutic efficacy against BCSCs. We determined CD44-targeting co-delivery nanoparticles are highly efficacious against BCSCs by inducing G1 cell cycle arrest and limiting epithelial–mesenchymal transition. This curcumin and salinomycin co-delivery system can be an efficient treatment approach to target malignant cancer without the repercussion of disease recurrence